Dysregulated hippocampal acetylcholine neurotransmission and impaired cognition in M2, M4 and M2/M4 muscarinic receptor knockout mice
نویسندگان
چکیده
منابع مشابه
Pronounced pharmacologic deficits in M2 muscarinic acetylcholine receptor knockout mice.
Members of the muscarinic acetylcholine receptor family (M1-M5) are known to be involved in a great number of important central and peripheral physiological and pathophysiological processes. Because of the overlapping expression patterns of the M1-M5 muscarinic receptor subtypes and the lack of ligands endowed with sufficient subtype selectivity, the precise physiological functions of the indiv...
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Stimulation of spinal muscarinic acetylcholine receptors (mAChRs) produces potent analgesia. Both M(2) and M(4) mAChRs are coupled to similar G proteins (G(i/o) family) and play a critical role in the analgesic action of mAChR agonists. To determine the relative contribution of M(2) and M(4) subtypes to activation of G(i/o) proteins in the spinal cord, we examined the receptor-mediated guanosin...
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1 Laboratory of Neuropsychiatry, Psychiatric Centre Copenhagen and Department ofNeuroscience and Pharmacology, University of Copenhagen, DK-2100 Copenhagen, Denmark; 2 Department of Public Health, Psychiatric Centre Copenhagen, University of Copenhagen, DK-2100 Copenhagen, Denmark; 3 Molecular Signaling Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institut...
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Adult mice communicate by emitting ultrasonic vocalizations (USVs) during the appetitive phases of sexual behavior. However, little is known about the genes important in controlling call production. Here, we study the induction and regulation of USVs in muscarinic and dopaminergic receptor knockout (KO) mice as well as wild-type controls during sexual behavior. Female mouse urine, but not femal...
متن کاملM1 AND M4 MUSCARINIC ACETYLCHOLINE RECEPTOR REGULATION OF NEUROTRANSMISSION AND CELL EXCITABILITY IN RODENT HIPPOCAMPUS AND PREFRONTAL CORTEX By
Muscarinic acetylcholine receptors (mAChRs), specifically M1 and M4 subtypes, provide viable targets for the treatment of multiple central nervous system disorders. However, highly selective activators of either M1 or M4 have not been available, making it difficult to determine the in vivo effects of selective activation of these receptors. We have used cheminformatics and medicinal chemistry t...
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ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2003
ISSN: 1359-4184,1476-5578
DOI: 10.1038/sj.mp.4001270